Table 5: Results of stability of FAV in human plasma under different storage conditions.

FAVIPIRAVIR

Storage Condition

Nominal Conc.

(ng/mL)

Mean Conc. Found

 (ng/mL)

CV (%)

RE (%)

Autosampler

240

235.451

2.397

-1.895

stabilitya

24000

24742.907

1.213

3.095

Short-term plasma

240

230.859

2.789

-3.809

stabilityb

24000

23991.154

1.565

-0.352

Long-term plasma

240

248.903

1.153

3.709

stabilityc

24000

24455.396

0.980

1.897

Freeze-thaw

240

228.217

2.356

-4.910

stabilityc

24000

24064.547

1.875

0.269

RE: Relative error (Accuracy); CV: Coefficient of Variation (Precision); SD: Standard Deviation; a: Kept at autosampler temperature, 10 °C; b: Stored at room temperature; c: Stored at -70 °C.