Table 5: Results of stability of FAV in human plasma under different storage conditions.
FAVIPIRAVIR |
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Storage Condition |
Nominal Conc. (ng/mL) |
Mean Conc. Found (ng/mL) |
CV (%) |
RE (%) |
Autosampler |
240 |
235.451 |
2.397 |
-1.895 |
stabilitya |
24000 |
24742.907 |
1.213 |
3.095 |
Short-term plasma |
240 |
230.859 |
2.789 |
-3.809 |
stabilityb |
24000 |
23991.154 |
1.565 |
-0.352 |
Long-term plasma |
240 |
248.903 |
1.153 |
3.709 |
stabilityc |
24000 |
24455.396 |
0.980 |
1.897 |
Freeze-thaw |
240 |
228.217 |
2.356 |
-4.910 |
stabilityc |
24000 |
24064.547 |
1.875 |
0.269 |
RE: Relative error (Accuracy); CV: Coefficient of Variation (Precision); SD: Standard Deviation; a: Kept at autosampler temperature, 10 °C; b: Stored at room temperature; c: Stored at -70 °C.