Table 6: Kinetic determination of FVS in capsule dosage forms by the proposed and reference methods.
Sample |
% Recovery ± SD |
||
Initial time method |
Fixed rate method |
Reference method [4] |
|
Fluvastatin 20 |
|||
Mean ± SDa |
101.13 ± 1.69 |
101.47 ± 1.48 |
101.18 ± 1.22 |
RSD% |
1.67 |
1.46 |
1.20 |
t-test |
1.72 |
2.04 |
1.84 |
F-test |
1.92 |
1.47 |
|
Almastatin 40 |
|||
Mean ± SDa |
101.29 ± 2.07 |
100.98 ± 1.95 |
100.19 ± 1.76 |
RSD% |
2.04 |
1.93 |
1.75 |
t-test |
1.48 |
1.77 |
1.36 |
F-test |
1.38 |
1.23 |
|
aMean and SD of five determinations. At 95% confidence limit the theoretical t and F-values at five degree of freedom are t = 2.776 and F = 6.26. |