Table 6: Kinetic determination of FVS in capsule dosage forms by the proposed and reference methods.

Sample

% Recovery ± SD

Initial time method

Fixed rate method

Reference method [4]

Fluvastatin 20

Mean ± SDa

101.13 ± 1.69

101.47 ± 1.48

101.18 ± 1.22

RSD%

1.67

1.46

1.20

t-test

1.72

2.04

1.84

F-test

1.92

1.47

 

Almastatin 40

Mean ± SDa

101.29 ± 2.07

100.98 ± 1.95

100.19 ± 1.76

RSD%

2.04

1.93

1.75

t-test

1.48

1.77

1.36

F-test

1.38

1.23

 

aMean and SD of five determinations.

At 95% confidence limit the theoretical t and F-values at five degree of freedom are t = 2.776 and F = 6.26.