Table 4: Estimation of times of different processes, delays, and decisions.
Description |
Probability Distribution† |
Avg. |
Std. Dev. |
|
Processes |
Check-in (lab/infusion/office visit) |
TRIA(0, 2, 5)* |
2.33 |
1.03 |
Lab test |
TRIA(22, 47.9, 120) |
63.30 |
20.73 |
|
Nurse evaluation |
TRIA(5, 15, 30)* |
16.67 |
5.14 |
|
Provider office visit |
UNIF(30, 60) |
45.0 |
8.66 |
|
Each nurse check |
TRIA(3, 5, 7)* |
5.0 |
0.82 |
|
Pharmacy check |
UNIF(10, 20) |
15.0 |
2.89 |
|
Pick/set up premeds‡ |
UNIF(10, 20) |
15.0 |
2.89 |
|
Pharmacist making chemos§ |
UNIF(15, 25) |
20 |
2.89 |
|
Infusion (regular: No reaction) |
TRIA(100, 120, 140) |
120 |
8.16 |
|
Infusion (with supportive care) |
TRIA(100, 120, 140) |
120 |
8.16 |
|
Infusion (with lowering the rate) |
110 + ERLA(51, 1) |
161.0 |
7.14 |
|
Patient discharge |
ERLA(29, 1) |
29.0 |
5.39 |
|
Each nurse involvement during walk around |
TRIA(1, 3, 5)* |
3.0 |
0.82 |
|
Inter-arrival time between walk arounds (when there is no reaction) |
TRIA(10, 15, 20) |
15.0 |
2.04 |
|
Inter-arrival time between walk arounds (when there is a reaction) |
TRIA(5, 10, 15) |
10.0 |
2.04 |
|
Delays |
Between activation of medication (by nurse) and modification made (by pharmacy) |
TRIA(10, 15, 20) |
15.0 |
2.04 |
Before chemotherapy start |
TRIA(10, 15, 20) |
15.0 |
2.04 |
|
Decisions |
Drug reaction (only for the 1st cycle) |
UNIF(0, 20) |
10 |
5.77 |
Strategy after reaction (for any cycle): Continue with supporting care Continue while lowering the rate Completely stop the infusion |
80 (all TDs)* 19 (TD = 1), 20 (TD ≥ 2)* 1 (TD = 1), 0 (TD ≥ 2)* |
- - - |
- - - |
|
Red flag |
UNIF(0, 50) (CYC = 1) |
25 |
14.43 |
|
UNIF(0, 10) (CYC ≥ 2) |
5 |
2.89 |
||
Go vs. no-go |
UNIF(30, 70)* |
50 |
11.55 |
|
Provider available |
99 |
- |
- |
†Instances shown by *are estimated based on expert opinions; ‡This process is done in parallel with the previous row (pharmacy check); §If there are multiple drugs, UNIF (5, 15) is added for each extra drug;
Unit for processes and delays: Minutes; Unit for decisions: %; CYC: Cycle; TD: Treatment Day; ERLA: Erlang Distribution; TRIA: Triangular Distribution; UNIF: Uniform Distribution.