Table 4: Estimation of times of different processes, delays, and decisions.

 Description Probability Distribution† Avg. Std. Dev. Processes Check-in (lab/infusion/office visit) TRIA(0, 2, 5)* 2.33 1.03 Lab test TRIA(22, 47.9, 120) 63.30 20.73 Nurse evaluation TRIA(5, 15, 30)* 16.67 5.14 Provider office visit UNIF(30, 60) 45.0 8.66 Each nurse check TRIA(3, 5, 7)* 5.0 0.82 Pharmacy check UNIF(10, 20) 15.0 2.89 Pick/set up premeds‡ UNIF(10, 20) 15.0 2.89 Pharmacist making chemos§ UNIF(15, 25) 20 2.89 Infusion (regular: No reaction) TRIA(100, 120, 140) 120 8.16 Infusion (with supportive care) TRIA(100, 120, 140) 120 8.16 Infusion (with lowering the rate) 110 + ERLA(51, 1) 161.0 7.14 Patient discharge ERLA(29, 1) 29.0 5.39 Each nurse involvement during walk around TRIA(1, 3, 5)* 3.0 0.82 Inter-arrival time between walk arounds (when there is no reaction) TRIA(10, 15, 20) 15.0 2.04 Inter-arrival time between walk arounds (when there is a reaction) TRIA(5, 10, 15) 10.0 2.04 Delays Between activation of medication (by nurse) and modification made (by pharmacy) TRIA(10, 15, 20) 15.0 2.04 Before chemotherapy start TRIA(10, 15, 20) 15.0 2.04 Decisions Drug reaction (only for the 1st cycle) UNIF(0, 20) 10 5.77 Strategy after reaction (for any cycle): Continue with supporting care Continue while lowering the rate Completely stop the infusion 80 (all TDs)* 19 (TD = 1), 20 (TD ≥ 2)* 1 (TD = 1), 0 (TD ≥ 2)* - - - - - - Red flag UNIF(0, 50) (CYC = 1) 25 14.43 UNIF(0, 10) (CYC ≥ 2) 5 2.89 Go vs. no-go UNIF(30, 70)* 50 11.55 Provider available 99 - -

Instances shown by *are estimated based on expert opinions; This process is done in parallel with the previous row (pharmacy check); §If there are multiple drugs, UNIF (5, 15) is added for each extra drug;

Unit for processes and delays: Minutes; Unit for decisions: %; CYC: Cycle; TD: Treatment Day; ERLA: Erlang Distribution; TRIA: Triangular Distribution; UNIF: Uniform Distribution.