Pharmacokinetic parameters of apigenin following oral administration of a single dose (60 mg/kg) of pure apigenin and apigenin-loaded mixed micelles (mean ± SD, n = 6).

Table 4: Pharmacokinetic parameters of apigenin following oral administration of a single dose (60 mg/kg) of pure apigenin and apigenin-loaded mixed micelles (mean ± SD, n = 6).

PK parameter	Pure apigenin	Apigenin-loaded mixed micelles
C_max(µg /mL)	2.32 ± 1.05	2.55 ± 1.27
T_max(h)	1.14 ± 0.95	6.03 ± 1.25
MRT (h)	6.48 ± 1.58	16.53 ± 4.82
t_1/2 (h)	1.44 ± 0.76	3.28 ± 1.51
AUC_(0→∞)(µg.h/mL)	14.94 ± 6.75	64.32 ± 17.43

Notes: C_max: Peak plasma concentration; T_max: Time to reach peak plasma concentration; MRT: Maximum Residence Time; T1/2: Elimination half-life; AUC(0→∞): Area under the plasma concentration time curve calculated by the linear trapezoidal rule from time 0 to infinity; SD: Standard Deviation